Amentoflavone has really started to make a breakthrough in the supplement industry recently. Where did this supplement come from and what are its major benefits and additions to the supplement industry? What products do we find this in and what are the uses behind this product? First of all Amentoflavone is a compound that can be extracted from many different plants (St. John’s Wort and Ginkgo Biloba). The reason this ingredient started to become popular after the turn of the century was the premise behind its anti-cancer and microbial properties.
What are the benefits?
Dating back to the turn of the century is when research on this ingredient was starting to take a turn and more information was becoming apparent. Things that were noted when searching through various pubmed articles included the following:
- increases in testosterone by releasing GnRH
- disinhibit excitatory neurotransmission
- aided fat loss
- increased vasodilation
- increases in muscular strength
- increases in muscular endurance
How can this aid in fat loss?
Beta-2 agonism can result during an increase of cAMP which helps to activate lipases and leads to fat breakdown or “lipolysis”. When beta-2 combines with phosphodiesterase isoenzyme found inside the adipose tissue this will aid the body in disposing of fat and aiding fatloss. This was also shown when research back into the late 1990’s when dosed on rats in an Italian lab overseas.
How can this aid in muscular strength and endurance?
Due to Amentoflavone being able to increase performance through vasodilation (this brings oxygen into the cells, and waste removal outside of them) to help meet demand of the exercising muscle tissue. Amento can also provide benefits for increasing power output on the individual during training. Due to the increase of CA2+ release the intracellular downstream can aid muscle contraction during training, and also increase cell volume. Due to this it also is a benefit towards caffeine making amento a binding agent which results nearly being twenty (20) times greater of the potency than caffeine.
What is the common dose?
Pre-workout is usually the most common dose of Amento as the effects on muscular strength, endurance, and fatloss can be found present. This has also been utilized in small forms of pre-workouts and fat burners on the market. Doses have ranged from 25mg to 175/200mg. With that being said most people will start to notice the effects of strength, pump, and fatloss even with around a 50mg range dose.
There is a law of diminishing returns as people can venture upward into the 100mg range or even higher but there is a law of diminishing returns when it comes to supplements and doses. Those who do end up utilizing high end doses are not at high risks of toxicity because that has been studied on a few studies that are posted on pubmed. (one from china in 1996 and one more recent in October 2014). The most studied dose by far has been pre-workout with a 25-50mg range, but there has also been signs of personal evidence with users spreading out amentoflavone dose throughout the day to aid in fatloss. The other products usually found on the market will be stimmed or non-stim pre-workout products which again would be the focus on pump (which has been stated in this article). There is also the effect towards strength gain where calcium is increased in the cell to aid a neutral stimulus response. Due to that response there is the increased result in contraction and an increase in force being produced.
Final Thoughts on Amentoflavone
The effects are still being studied as it’s relatively new to the market. The results for amentoflavone are not 100% conclusive but it is becoming far more popular. Due to the benefits of increasing strength and pump (Calcium increased in the cell and an increase of vasodilation) there are benefits to see this stacked in a pre-workout or non-stimulated pre-workout formula. Fatloss is shown when adipose (fat) tissue and cAMP levels are increased due to the b2 agonist that helps intracellular cAMP. The increase in lipolysis which breakdown stored fat inhibits PDE, PDE which is responsible for the breakdown of cAMP and the aid of fatloss.
Lastly Insulin Sensitivity has productivity in this ingredient where the enzyme PTP1B is involved with insulin signaling in the body. There has been research done on PTP1B and the effects regarding obesity and diabetes in American hospitals. The PTP1B inhibition shows a direct correlation towards insulin sensitivity. The insulin sensitivity reducing circulating lipids (which would be LDL/triglycerides) is a main benefit towards those with obesity or diabetes.